About Female Sex Hormon
Progesterone is a female sex hormone. It is produced mainly in the ovaries following ovulation each month. It is a crucial part of the menstrual cycle and maintenance of pregnancy. One of the most important functions of Progesterone is thickening the lining of the uterus each month. This lining is prepared to receive a nourished and fertilized egg. Without the thickened lining of the uterus, reproduction wouldn’t be successful.
Low Progesterone levels leads to-
A) Gynecological Disorders:
1. Premenstrual Syndrome
2. Abnormal Uterine Bleeding (AUB)
3. Irregular or painful menstruation
4. Endometriosis
5. Infertility
B) Pregnancy Related Disorders:
1. Vaginal bleeding in pregnancy/ Threatened Abortion
2. Recurrent pregnancy loss/ Recurrent miscarriage
Symptoms of Progesterone deficiency:
Irregular menstrual periods, mood changes, anxiety or depression, difficulty conceiving, hot flashes, miscarriage etc.
Treatment options for Progesterone deficiency:
a)Norethisterone: It used in abnormal uterine bleeding.
b) Hydroxyprogesterone: It used in prevention of preterm birth.
c) Progesterone: It used in abortion & reproductive system related problems.
d) Allylestrenol: It used in prevention of miscarriage.
e)Dienogest: It used in prevention of endometriosis.
f) Lynestrenol: It used in prevention of menstrual cycle related problems.
g) Medroxyprogesterone: It used in prevention of amenorrhea & abnormal uterine bleeding.
h)Dydrogesterone: It used in abortion & reproductive system related problems.
Dydrogesterone is an orally active synthetic progesterone used for menstrual cycle regulation, infertility treatment, prevention of miscarriage, and other conditions. Dydrogesterone is a highly selective progestogen, and due to its unique structure, binds almost exclusively to the progesterone receptor (PR). At therapeutic levels, Dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, Dydrogesterone is non-androgenic, non-estrogenic, non-corticoid, non-anabolic. It rapidly absorbed in the gastrointestinal tract with a bioavailability of 28%.