Basic Mechanism of Action of NSAID (Part-03)

 Product Name: Sonap

Generic Name: Naproxen

Mechanism of Action:

The mechanism of action of naproxen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase (both) activity.

Product Name: Xenole
Generic Name: Naproxen + Esomeprazole

Mechanism of Action:

Xenole consists of an immediate release Esomeprazole magnesium layer and an enteric coated Naproxen core. As a result, Esomeprazole is released first into the stomach, prior to the dissolution of Naproxen in the small intestine.
Naproxen is a NSAID with analgesic and antipyretic properties.
The mechanism of action of Naproxen is to inhibition of the prostaglandin synthesis. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell.

By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.

Product Name: Xenole
Generic Name: Naproxen + Esomeprazole

Mechanism of Action:

Xenole consists of an immediate release Esomeprazole magnesium layer and an enteric coated Naproxen core. As a result, Esomeprazole is released first into the stomach, prior to the dissolution of Naproxen in the small intestine.
Naproxen is a NSAID with analgesic and antipyretic properties.
The mechanism of action of Naproxen is to inhibition of the prostaglandin synthesis. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell.
By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.

Product Name: Xflam
Generic Name: Dexibuprofen

Mechanism of Action:

Dexibuprofen inhibits prostaglandin synthesis via blockade of cyclooxygenase (COX) enzymes. Dexibuprofen inhibits both COX-1 and COX-2 and shows anti-inflammatory property.

Product Name: Xten
Generic Name: Tenoxicam

Mechanism of Action:

The anti-inflammatory effects of tenoxicam may result from the inhibition of the enzyme cyclooxygenase (both COX-1 & COX-2) and the subsequent peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, their inhibition accounts for the peripheral analgesic effects of tenoxicam.